• Nicotinamide adenine dinucleotide (NAD+) is an important coenzyme that plays a crucial role in various metabolic pathways in the body. Here are some reasons why NAD+ is important:
• Energy production: NAD+ is essential for the production of energy in the form of ATP through cellular respiration. It acts as a coenzyme in the conversion of glucose into ATP, which is used to power cellular processes.
• DNA repair: NAD+ is involved in DNA repair mechanisms in cells, which are essential for maintaining the integrity of the genetic material and preventing mutations that could lead to cancer and other diseases.
• Cellular signaling: NAD+ is involved in various cellular signaling pathways that control important biological processes such as cell differentiation, cell death, and immune function.
• Anti-aging: NAD+ levels in cells decrease with age, and this has been linked to various age-related diseases. NAD+ supplements have been shown to have anti-aging effects by improving mitochondrial function, reducing inflammation, and enhancing DNA repair mechanisms.
• Overall, NAD+ is essential for many fundamental biological processes in the body, and maintaining adequate levels of this coenzyme is important for overall health and well-being

NAD+ is a coenzyme that is produced naturally by the body, but its levels can decrease with age or due to other factors such as poor diet or certain medical conditions. There are several ways to increase NAD+ levels, including:

Supplements: NAD+ supplements are available in various forms, including capsules, powders, and intravenous infusions. These supplements are often derived from nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN), which are precursors to NAD+.

Foods: Foods that are rich in the precursor to NAD+, such as tryptophan, niacin, and nicotinamide, can help boost NAD+ levels in the body. Examples include poultry, fish, nuts, and legumes.

Exercise: Regular exercise has been shown to increase NAD+ levels in the body, particularly in skeletal muscle.

Fasting: Short-term fasting has been shown to increase NAD+ levels in the body, likely due to the activation of a cellular stress response called autophagy.

It is important that NAD+ supplements are taken under the guidance of a healthcare professional.

Yes, Definitely. NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in all living cells that plays a crucial role in cellular energy metabolism and signaling. There is growing interest in the use of NAD+ supplements as a potential tool for improving health outcomes.

• Several studies have investigated the benefits of NAD+ supplementation, particularly for age-related conditions such as cognitive decline, metabolic dysfunction, and cardiovascular disease. A randomized controlled trial in humans found that a daily dose of NAD+ precursor, nicotinamide riboside (NR), for six weeks increased levels of NAD+ in blood cells and improved insulin sensitivity (Study 1, Reference 1).
• Another study found that long-term supplementation with NR improved muscle function and decreased muscle inflammation in aged mice (Study 2, Reference 2).
• In addition to its potential effects on aging-related conditions, NAD+ supplementation has also been studied for its potential benefits in cancer treatment. A study in mice found that NAD+ depletion sensitized cancer cells to chemotherapy (Study 3, Reference 3).
• There is also evidence to suggest that NAD+ supplements may have benefits for neurological conditions. A study in mice found that NAD+ supplementation protected against neurodegeneration in a model of Parkinson’s disease (Study 4, Reference 4).

While the potential benefits of NAD+ supplementation are promising, more research is needed to fully understand its mechanisms and potential side effects. Additionally, the quality and purity of NAD+ supplements on the market may vary, making it important to choose a reputable source, that’s where we come in.

Overall, the evidence suggests that NAD+ supplementation may have potential health benefits, particularly for age-related conditions and neurological disorders. However, further research is needed to fully understand its efficacy and safety.

References for above studies:

• Elhassan YS, Kluckova K, Fletcher RS, et al. Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signaling Responses. Cell Rep. 2019;28(7):1717-1728.e6. doi:10.1016/j.celrep.2019.07.043
• Frederick DW, Davis JG, Davila A Jr, et al. Increasing NAD Synthesis in Muscle via Nicotinamide Phosphoribosyltransferase Is Not Sufficient to Promote Oxidative Metabolism. J Biol Chem. 2015;290(24):15456-15464. doi:10.1074/jbc.M115.660496
• Hasmann M, Schemainda I. FK866/K22 and the Quinoline- and Quinoxaline-based Compounds, Inhibitors of NAD Synthesis, Induce G1 Arrest in Human Cancer Cells. Cell Cycle. 2003;2(6):501-508. doi:10.4161/cc.2.6.535
• Wang X, Hu X, Yang Y, Takata T, Sakurai T. Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death. Brain Res. 2016;1643:1-9. doi:10.1016/j.brainres.2016.03.009

Here are some of the benefits of NAD+ supplements, which you can expect:

1. Protects cells from stress: NAD+ helps protect cells from stress-induced damage by repairing DNA and preventing oxidative stress.
2. Maintains healthy sleep cycles: NAD+ is involved in regulating the body’s circadian rhythms, which helps maintain healthy sleep cycles.
3. Helps your cells repair damaged DNA: NAD+ helps repair damaged DNA by activating enzymes that are involved in DNA repair.
4. Activates enzymes that may promote healthy aging: NAD+ activates sirtuins, a group of enzymes that play a key role in promoting healthy aging by regulating gene expression and cellular metabolism.
5. Helps to banish addiction: NAD+ therapy has been used to help people overcome addiction by reducing cravings and withdrawal symptoms.
6. Provides a metabolism boost: NAD+ is involved in cellular metabolism and can help boost metabolism, which can lead to increased energy levels.
7. Improves cognitive function: NAD+ is involved in the production of ATP, the body’s primary source of energy, which can improve cognitive function and mental clarity.

NR (Nicotinamide Riboside) is a form of vitamin B3 that has been found to boost NAD+ levels in the body. NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme that plays a critical role in many metabolic processes, including energy production, DNA repair, and gene expression.

NR works by being converted into NAD+ by a series of enzymes in the body. This process, known as the salvage pathway, involves several steps, with NR being converted to NMN (Nicotinamide Mononucleotide) and then to NAD+. By providing a source of NR, the body can increase its production of NAD+, which can have numerous benefits for overall health and wellness.

Boosting NAD+ levels with NR has been shown to have several potential benefits, including improved mitochondrial function, increased energy production, enhanced DNA repair, and improved metabolic health. NR has also been studied for its potential anti-aging properties, as NAD+ levels decline with age and may contribute to age-related diseases.

NR is a promising compound for boosting NAD+ levels and improving overall health and wellness. However, as with any supplement or medication, it is important to speak with a healthcare provider before beginning NR supplementation, particularly if you have any underlying health conditions or are taking any medications.

Yes, there is ample amount of research available on this. In a study conducted on mice, it was found that NR supplementation increased NAD+ levels in several tissues, including the liver and muscle, and improved mitochondrial function and physical performance (Cantó et al., 2012).

In a human study, researchers found that NR supplementation increased NAD+ levels in blood and muscle tissue and improved muscle mitochondrial function (Trammell et al., 2016).

Another study conducted on healthy middle-aged and older adults found that NR supplementation increased NAD+ levels and improved blood pressure, arterial stiffness, and cognitive function (Martens et al., 2018).

A randomized, double-blind, placebo-controlled study found that daily supplementation of NR increased NAD+ levels in healthy adults and improved blood pressure and arterial stiffness (Dellinger et al., 2017).

Overall, these studies suggest that NR supplementation can effectively increase NAD+ levels in both animals and humans and improve various age-related conditions. However, more research is needed to determine the long-term safety and efficacy of NR supplementation.